Guanghong Jia, Ph.D.
Assistant Professor, Department of Medicine-EndocrinologyOffice Location: MSB MA436A
Office Phone: 573-882-8805
Jiag@health.missouri.edu
Research Interests
Insulin resistance and obesity related cardiovascular disease
Research Description
My laboratory has a principal interest in understanding the molecular mechanisms of obesity-associated insulin resistance, vascular and cardiac dysfunction. Current projects identify novel pathways by which the endothelium regulates vessel and target organ function through the mineralocorticoid receptors. Our studies explore novel kinase pathways and, recently, incorporate novel nano-techniques and therapeutics by utilizing in vitro cell culture and in vivo gene knockout mouse models.
Professional Background
- Obtained BS in Biomedical Science in Hubei Medical University, China
- Obtained PhD in Biomedical Science in Huazhong University of Science and Technology, China
- Completed postdoctoral training in Creighton University School of Medicine, Omaha, NE
Selected Publications
Hulse JL, Habibi J, Igbekele AE, Zhang B, Li J, Whaley-Connell A, Sowers JR, Jia G. Mineralocorticoid receptors mediate diet – induced lipid infiltration of skeletal muscle and insulin resistance. Endocrinology. 2022;163:bqac145.
Habibi J, DeMarco V, Hulse JL, Hayden MR, Whaley-Connell A, Hill MA, Sowers JR, and Jia G. Inhibition of sphingomyelinase attenuates diet - induced increases in aortic stiffness. J Mol Cell Cardiol. 2022;167:32-39.
Habibi J, Chen D, Hulse JL, Whaley-Connell A, Sowers JR, and Jia G. Targeting mineralocorticoid receptors in diet – induced hepatic steatosis and insulin resistance. Am J Physiol Regul Integr Comp Physiol. 2022;322:R253-R262.
Jia G, Sowers JR. Hypertension in Diabetes: An updated of basic mechanisms and clinical disease. Hypertension. 2021. 78:1197-1205.
Sowers JR, Habibi J, Aroor AR, Yang Y, Lastra G, Hill MA, Whaley-Connell A, Jaisser F, Jia G. Epithelial sodium channel in endothelial cells mediate diet- induced endothelium stiffness and impaired vascular relaxation in obese female mice. Metabolism. 2019;99:57-66.
Jia G, Habibi J, Aroor AR, Hill MA, Yang Y, Whaley-Connell A, Jaisser F, Sowers JR. Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction. Hypertension. 2018. 72:731-738.
Jia G, Hill MA, Sowers JR. Diabetic cardiomyopathy: An Update of mechanisms contributing to this clinical entity. Circ Res. 2018;122:624-638.
Jia G, Habibi J, Aroor AR, Martinez-Lemus LA, DeMarco VG, Ramirez-Perez FI, Sun Z, Hayden MR, Meininger GA, Barrett Mueller KV, Jaffe IZ, Sowers JR. Endothelial Mineralocorticoid Receptor Mediates Diet Induced Aortic Stiffness in Females. Circ Res. 2016; 118:935-943.
Jia G, Habibi J, DeMarco VG, Martinez-Lemus LA, Ma L, Whaley-Connell AT, Aroor AR, Domeier TL, Zhu Y, Meininger GA, Barrett Mueller K, Jaffe IZ, Sowers JR. Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females. Hypertension. 2015;66:1159-67.
