Dalton Cardiovascular Research Center

University of Missouri

Chetan P. Hans, Ph.D.

Assistant Professor, Department of Medicine-Cardiology
Office Location: Dalton 324B
Office Phone: 573-882-2427
hanscp@health.missouri.edu

Research Interests

Abdominal aortic aneurysm

Research Description

The overall objective of this proposal is to determine if myeloid-specific Notch1 deficiency prevents or reverses AAA progression. My central hypothesis is that deficiency of Notch1 promotes differentiation of Mφ towards a M2-phenotype by a TGF-β2 dependent mechanism(s), which attenuates the inflammatory response and protects against AAA development. Successful completion of this project will provide insight into the cellular and molecular mechanisms by which loss of Notch1 signaling in macrophages prevents the progression of AAA, and ultimately may provide the basis for novel therapeutic approaches based on M2 differentiation of Mφ to treat AAA in humans.

Professional Background

• Institute of Chemists, Calcutta, India 1993-95 M.Sc. Biochemistry
• Panjab University, Chandigarh, India 1998-02 Ph.D. Biochemistry
• Research Fellow at Mississippi State University, MS 2003 - 2005
• Research Fellow at LSUHSC, New Orleans 2005 – 2007
• Senior Research Fellow at LSUHSC, New Orleans 2007 – 2009
• Assistant Professor (research track) at The OSU College of Medicine 2009- 2012
• Principal Investigator at Nationwide Children's Hospital 2009 – 2016
• Assistant Professor (tenure track) at The OSU College of Medicine 2012-2016

Selected Publications

• Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression. Sachdeva J, Mahajan A, Cheng J, Baeten JT, Lilly B, Kuivaniemi H, Hans CP.  PLoS One. 2017 May 31;12(5):e0178538. doi: 10.1371/journal.pone.0178538. eCollection 2017. PMID: 28562688
• Cheng J, Koenig SN, Kuivaniemi HS, Garg V, Hans CP. Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model. Journal of the American Heart Association.3; 2014.
• Hans CP, Koenig SN, Huang N, Cheng J, Beceiro S, Guggilam A, Kuivaniemi H, Partida-Sánchez S, and Garg V. Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology 32: 3012-3023, 2012.
• Zhao N, Koenig SN, Trask AJ, Lin C-h, Hans CP, Garg V, Lilly B. Mir145 regulates tgfbr2 expression and matrix synthesis in vascular smooth muscle cells. Circulation Research. 2014.
• Bosse K*, Hans CP*, Zhao N*, Koenig SN, Huang N, Guggilam A, LaHaye S, Tao G, Lucchesi PA, Lincoln J, Lilly B, Garg V. Endothelial nitric oxide signaling regulates notch1 in aortic valve disease. Journal of Molecular and Cellular Cardiology. 60:27-35, 2013. *Equal contribution
• Acharya A*, Hans CP*, Koenig SN, Nichols HA, Galindo CL, Garner HR, Merrill WH, Hinton RB, and Garg V. Inhibitory role of notch1 in calcific aortic valve disease. PLoS One 6 (11): e27743, 2011. *Equal contribution
• Hans CP, Zerfaoui M, Naura A, Troxclair D, Strong JP, Matrougui K, Boulares H. Thieno[2,3-c]isoquinolin-5-one (TIQ-A), a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high fat diet-fed ApoE-deficient mice: effects on inflammatory markers and lipid content. J Pharmacol Exp Ther 329(1):150-8, 2009.